[HTML][HTML] Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway
SS Choi, WK Syn, GF Karaca, A Omenetti… - Journal of Biological …, 2010 - ASBMB
Trans-differentiation of quiescent hepatic stellate cells (Q-HSCs), which exhibit epithelial
and adipocytic features, into myofibroblastic-HSC (MF-HSCs) is a key event in liver fibrosis.
Culture models demonstrated that Hedgehog (Hh) pathway activation is required for
transition of epithelioid/adipocytic Q-HSCs into MF-HSCs. Hh signaling inhibits adiposity
and promotes epithelial-to-mesenchymal transitions (EMTs). Leptin (anti-adipogenic, pro-
EMT factor) promotes HSC trans-differentiation and liver fibrosis, suggesting that the …
and adipocytic features, into myofibroblastic-HSC (MF-HSCs) is a key event in liver fibrosis.
Culture models demonstrated that Hedgehog (Hh) pathway activation is required for
transition of epithelioid/adipocytic Q-HSCs into MF-HSCs. Hh signaling inhibits adiposity
and promotes epithelial-to-mesenchymal transitions (EMTs). Leptin (anti-adipogenic, pro-
EMT factor) promotes HSC trans-differentiation and liver fibrosis, suggesting that the …