Biosynthesis of proTRH-derived peptides in prohormone convertase 1 and 2 knockout mice
NE Cyr, RC Stuart, X Zhu, DF Steiner, EA Nillni - Peptides, 2012 - Elsevier
Prohormone convertases (PCs) 1 and 2 are the primary endoproteases involved in the post-
translational processing of proThyrotropin Releasing Hormone (proTRH) to give rise to TRH
and other proposed biologically active non-TRH peptides. Previous evidence suggests that
PC1 is responsible for most proTRH cleavage events. Here, we used the PC1 and PC2
knockout (KO) mouse models to examine the effects of PC1 or PC2 loss on proTRH
processing. The PC1KO mouse presented a decrease in five proTRH-derived peptides …
translational processing of proThyrotropin Releasing Hormone (proTRH) to give rise to TRH
and other proposed biologically active non-TRH peptides. Previous evidence suggests that
PC1 is responsible for most proTRH cleavage events. Here, we used the PC1 and PC2
knockout (KO) mouse models to examine the effects of PC1 or PC2 loss on proTRH
processing. The PC1KO mouse presented a decrease in five proTRH-derived peptides …