Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases.

CF Reilly, DA Tewksbury, NM Schechter… - Journal of Biological …, 1982 - ASBMB
Human neutrophil cathepsin G and human skin mast cell chymase rapidly convert
angiotensin I to angiotensin II with only minor cleavage elsewhere in the molecule. The rate
of cleavage is consistent with a potential role for either or both of these enzymes in an
alternate pathway for angiotensin II synthesis. Since neither enzyme in inhibited by captopril,
an angiotensin converting enzyme inactivator, it is possible that leukocyte and mast cell
enzymes may play a significant role in the development of abnormally high local …