Immunosuppressive effects of apoptotic cells

RE Voll, M Herrmann, EA Roth, C Stach, JR Kalden… - Nature, 1997 - nature.com
RE Voll, M Herrmann, EA Roth, C Stach, JR Kalden, I Girkontaite
Nature, 1997nature.com
Apoptotic cell death is important in the development and homeostasis of multicellular
organisms and is a highly controlled means of eliminating dangerous, damaged or
unnecessary cells without causing an inflammatory response or tissue damage,. We now
show that the presence of apoptotic cells during monocyte activation increases their
secretion of the anti-inflammatory and immunoregulatory cytokine interleukin 10 (IL-10) and
decreases secretion of the proinflammatory cytokines tumour necrosis factor-α (TNF-α), IL-1 …
Abstract
Apoptotic cell death is important in the development and homeostasis of multicellular organisms and is a highly controlled means of eliminating dangerous, damaged or unnecessary cells without causing an inflammatory response or tissue damage,. We now show that the presence of apoptotic cells during monocyte activation increases their secretion of the anti-inflammatory and immunoregulatory cytokine interleukin 10 (IL-10) and decreases secretion of the proinflammatory cytokines tumour necrosis factor-α (TNF-α), IL-1 and IL-12. This may inhibit inflammation and contribute to impaired cell-mediated immunity in conditions associated with increased apoptosis, such as viral infections, pregnancy, cancer and exposure to radiation.
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