[HTML][HTML] FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1
S Khatri, H Yepiskoposyan, CA Gallo, P Tandon… - Journal of biological …, 2010 - ASBMB
Akt signal transduction induces coordinated increases in glycolysis and apoptosis
resistance in a broad spectrum of cancers. Downstream of Akt, the FoxO transcription factors
regulate apoptosis via Bim, but the contributions of FoxOs in regulating Akt-induced
glycolysis are not well described. We find that FoxO3a knockdown is sufficient to induce
apoptosis resistance in conjunction with elevated glycolysis. Glycolysis in FoxO3a-deficient
cells was associated with increased S6K1 phosphorylation and was sensitive to rapamycin …
resistance in a broad spectrum of cancers. Downstream of Akt, the FoxO transcription factors
regulate apoptosis via Bim, but the contributions of FoxOs in regulating Akt-induced
glycolysis are not well described. We find that FoxO3a knockdown is sufficient to induce
apoptosis resistance in conjunction with elevated glycolysis. Glycolysis in FoxO3a-deficient
cells was associated with increased S6K1 phosphorylation and was sensitive to rapamycin …