[HTML][HTML] Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade
SS Ng, T Mahmoudi, E Danenberg, I Bejaoui… - Journal of Biological …, 2009 - ASBMB
Mutational activation of the phosphatidylinositol 3-kinase (PI3K) pathway occurs in a wide
variety of tumors, whereas activating Wnt pathway mutants are predominantly found in colon
cancer. Because GSK3 is a key component of both pathways, it is widely assumed that
active PI3K signaling feeds positively into the Wnt pathway by protein kinase B (PKB)-
mediatefd inhibition of GSK3. In addition, PKB has been proposed to modulate the canonical
Wnt signaling through direct stabilization and nuclear localization of β-catenin. Here, we …
variety of tumors, whereas activating Wnt pathway mutants are predominantly found in colon
cancer. Because GSK3 is a key component of both pathways, it is widely assumed that
active PI3K signaling feeds positively into the Wnt pathway by protein kinase B (PKB)-
mediatefd inhibition of GSK3. In addition, PKB has been proposed to modulate the canonical
Wnt signaling through direct stabilization and nuclear localization of β-catenin. Here, we …