[HTML][HTML] Inhibition of the phosphatidylinositol 3-kinase/p70S6-kinase pathway induces B16 melanoma cell differentiation
C Bertolotto, JP Ortonne, R Ballotti - Journal of Biological Chemistry, 1996 - ASBMB
α-Melanocyte-stimulating hormone and cAMP-elevating agents are known to induce B16
cell differentiation, characterized by increased melanin synthesis and dendrite outgrowth. In
order to elucidate intracellular signaling pathways involved in this differentiation process, we
focused our interest on the phosphatidylinositol 3-kinase/p70 S6-kinase pathway. The
specific inhibition of phosphatidylinositol 3-kinase by LY294002 markedly stimulated
dendrite outgrowth, thus mimicking the action of cAMP-elevating agents on B16 cell …
cell differentiation, characterized by increased melanin synthesis and dendrite outgrowth. In
order to elucidate intracellular signaling pathways involved in this differentiation process, we
focused our interest on the phosphatidylinositol 3-kinase/p70 S6-kinase pathway. The
specific inhibition of phosphatidylinositol 3-kinase by LY294002 markedly stimulated
dendrite outgrowth, thus mimicking the action of cAMP-elevating agents on B16 cell …