[HTML][HTML] WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition
H Ho, R Kapadia, S Al-Tahan, S Ahmad… - Journal of Biological …, 2011 - ASBMB
Recent studies implicate a role for WD repeat domain, phosphoinositide-interacting 1
(WIPI1) in the biogenesis of melanosomes, cell type-specific lysosome-related organelles. In
this study, we determined that WIPI1, an ATG18 homologue that is shown to localize to both
autophagosomes and early endosomes, inhibited mammalian target of rapamycin (MTOR)
signaling, leading to increased transcription of melanogenic enzymes and the formation of
mature melanosomes. WIPI1 suppressed the target of rapamycin complex 1 (TORC1) …
(WIPI1) in the biogenesis of melanosomes, cell type-specific lysosome-related organelles. In
this study, we determined that WIPI1, an ATG18 homologue that is shown to localize to both
autophagosomes and early endosomes, inhibited mammalian target of rapamycin (MTOR)
signaling, leading to increased transcription of melanogenic enzymes and the formation of
mature melanosomes. WIPI1 suppressed the target of rapamycin complex 1 (TORC1) …