Immunological and inflammatory functions of the interleukin-1 family
CA Dinarello - Annual review of immunology, 2009 - annualreviews.org
More than any other cytokine family, the interleukin (IL)-1 family is closely linked to the
innate immune response. This linkage became evident upon the discovery that the
cytoplasmic domain of the IL-1 receptor type I is highly homologous to the cytoplasmic
domains of all Toll-like receptors (TLRs). Thus, fundamental inflammatory responses such
as the induction of cyclooxygenase type 2, increased expression of adhesion molecules, or
synthesis of nitric oxide are indistinguishable responses of both IL-1 and TLR ligands. Both …
innate immune response. This linkage became evident upon the discovery that the
cytoplasmic domain of the IL-1 receptor type I is highly homologous to the cytoplasmic
domains of all Toll-like receptors (TLRs). Thus, fundamental inflammatory responses such
as the induction of cyclooxygenase type 2, increased expression of adhesion molecules, or
synthesis of nitric oxide are indistinguishable responses of both IL-1 and TLR ligands. Both …
