Long-term efficacy of topical fluorouracil cream, 5%, for treating actinic keratosis: a randomized clinical trial
H Pomerantz, D Hogan, D Eilers, SM Swetter… - JAMA …, 2015 - jamanetwork.com
Importance Topical fluorouracil was demonstrated to be effective in reducing the number of
actinic keratoses (AKs) for up to 6 months, but no randomized trials studied its long-term
efficacy. Objective To evaluate the long-term efficacy of a single course of fluorouracil cream,
5%, for AK treatment. Design, Setting, and Participants The Veterans Affairs Keratinocyte
Carcinoma Chemoprevention (VAKCC) trial was a randomized, double-blinded, placebo-
controlled trial with patients from dermatology clinics at 12 VA medical centers recruited from …
actinic keratoses (AKs) for up to 6 months, but no randomized trials studied its long-term
efficacy. Objective To evaluate the long-term efficacy of a single course of fluorouracil cream,
5%, for AK treatment. Design, Setting, and Participants The Veterans Affairs Keratinocyte
Carcinoma Chemoprevention (VAKCC) trial was a randomized, double-blinded, placebo-
controlled trial with patients from dermatology clinics at 12 VA medical centers recruited from …