5-Fluorouracil and interferon-α immunochemotherapy enhances immunogenicity of murine pancreatic cancer through upregulation of NKG2D ligands and MHC class …
H Khallouf, A Märten, S Serba… - Journal of …, 2012 - journals.lww.com
Pancreatic cancer has the poorest prognosis of all gastrointestinal cancers, driving the need
for new therapeutic approaches. Adjuvant 5-fluorouacil (5-FU) chemotherapy proved
effective in increasing the survival of patients with resected tumors. Furthermore, the addition
of interferon alpha (IFN-α) immunotherapy to 5-FU has shown encouraging clinical results.
The aim of this study was to determine the relevance of different immune cell populations,
namely natural killer (NK) cells, CD8 T cells, and dendritic cells, in the anticancer immune …
for new therapeutic approaches. Adjuvant 5-fluorouacil (5-FU) chemotherapy proved
effective in increasing the survival of patients with resected tumors. Furthermore, the addition
of interferon alpha (IFN-α) immunotherapy to 5-FU has shown encouraging clinical results.
The aim of this study was to determine the relevance of different immune cell populations,
namely natural killer (NK) cells, CD8 T cells, and dendritic cells, in the anticancer immune …