[HTML][HTML] Metformin inhibits the production of reactive oxygen species from NADH: ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts …
Metformin, a frontline treatment for type II diabetes mellitus, decreases production of the pro-
form of the inflammatory cytokine IL-1β in response to LPS in macrophages. We found that it
specifically inhibited pro-IL-1β production, having no effect on TNF-α. Furthermore,
metformin boosted induction of the anti-inflammatory cytokine IL-10 in response to LPS. We
ruled out a role for AMP-activated protein kinase (AMPK) in the effect of metformin because
activation of AMPK with A769662 did not mimic metformin here. Furthermore, metformin was …
form of the inflammatory cytokine IL-1β in response to LPS in macrophages. We found that it
specifically inhibited pro-IL-1β production, having no effect on TNF-α. Furthermore,
metformin boosted induction of the anti-inflammatory cytokine IL-10 in response to LPS. We
ruled out a role for AMP-activated protein kinase (AMPK) in the effect of metformin because
activation of AMPK with A769662 did not mimic metformin here. Furthermore, metformin was …