Recent studies show that hepatocyte growth factor (HGF) has potent anti-inflammatory
effects in multiple animal models of disease in various organ systems, including the kidney,
suggesting that HGF may suppress a common proinflammatory process. The aim of this
study was to examine the molecular mechanism of HGF's anti-inflammatory actions in a
model of chronic kidney disease. Beginning 2 wk after subtotal nephrectomy, rats received a
continuous infusion of recombinant HGF, neutralization of endogenous HGF by daily …