[HTML][HTML] Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4
O Gealekman, K Gurav, M Chouinard… - Journal of Biological …, 2014 - ASBMB
Adipose tissue expansion requires growth and proliferation of adipocytes and the
concomitant expansion of their stromovascular network. We have used an ex vivo
angiogenesis assay to study the mechanisms involved in adipose tissue expansion. In this
assay, adipose tissue fragments placed under pro-angiogenic conditions form sprouts
composed of endothelial, perivascular, and other proliferative cells. We find that sprouting
was directly stimulated by insulin and was enhanced by prior treatment of mice with the …
concomitant expansion of their stromovascular network. We have used an ex vivo
angiogenesis assay to study the mechanisms involved in adipose tissue expansion. In this
assay, adipose tissue fragments placed under pro-angiogenic conditions form sprouts
composed of endothelial, perivascular, and other proliferative cells. We find that sprouting
was directly stimulated by insulin and was enhanced by prior treatment of mice with the …