[HTML][HTML] Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus
BH Goodpaster, FL Thaete, DE Kelley - The American journal of clinical …, 2000 - Elsevier
Background: Adipose tissue (AT) content of the thigh is generally not considered to be
associated with insulin resistance (IR), but it is unclear whether the distribution of AT in the
thigh is a determinant of IR. Objective: We investigated whether subcompartments of AT
within the thigh are determinants of IR. Design: Midthigh AT, muscle composition, and
insulin sensitivity were compared in 11 obese patients with type 2 diabetes mellitus (DM); 40
obese, glucose-tolerant (GT) and 15 lean, GT volunteers; and 38 obese subjects who …
associated with insulin resistance (IR), but it is unclear whether the distribution of AT in the
thigh is a determinant of IR. Objective: We investigated whether subcompartments of AT
within the thigh are determinants of IR. Design: Midthigh AT, muscle composition, and
insulin sensitivity were compared in 11 obese patients with type 2 diabetes mellitus (DM); 40
obese, glucose-tolerant (GT) and 15 lean, GT volunteers; and 38 obese subjects who …