Skeletal muscle plays important roles in whole-body glucose and fatty acid metabolism.
However, muscle also secretes cytokines and growth factors (collectively termed myokines)
that can potentially act in an autocrine, a paracrine, and/or an endocrine manner to
modulate metabolic, inflammatory, and other processes. Here, we report the identification
and characterization of myonectin, a novel myokine belonging to the C1q/TNF-related
protein (CTRP) family. Myonectin transcript was highly induced in differentiated myotubes …