Increased protein kinase C theta in skeletal muscle of diabetic patients
SI Itani, WJ Pories, KG MacDonald… - Metabolism-Clinical …, 2001 - metabolismjournal.com
In this study we have investigated whether protein kinase C (PKC) protein and activity are
increased in skeletal muscle of human diabetic patients. The protein content of different PKC
isoforms (β, Θ, ϵ, δ, μ, and ζ) in the particulate fraction was measured, using Western
analysis, in human rectus abdominus skeletal muscle from obese (hyperinsulinemic,
normoglycemic) and obese diabetic (hyperinsulinemic, hyperglycemic) subjects. PKC Θ
protein content was significantly higher in the particulate fraction of muscle from diabetic …
increased in skeletal muscle of human diabetic patients. The protein content of different PKC
isoforms (β, Θ, ϵ, δ, μ, and ζ) in the particulate fraction was measured, using Western
analysis, in human rectus abdominus skeletal muscle from obese (hyperinsulinemic,
normoglycemic) and obese diabetic (hyperinsulinemic, hyperglycemic) subjects. PKC Θ
protein content was significantly higher in the particulate fraction of muscle from diabetic …