[HTML][HTML] Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex
Z Gao, D Hwang, F Bataille, M Lefevre, D York… - Journal of Biological …, 2002 - ASBMB
Insulin resistance contributes importantly to the pathophysiology of type 2 diabetes mellitus.
One mechanism mediating insulin resistance may involve the phosphorylation of serine
residues in insulin receptor substrate-1 (IRS-1), leading to impairment in the ability of IRS-1
to activate downstream phosphatidylinositol 3-kinase-dependent pathways. Insulin-resistant
states and serine phosphorylation of IRS-1 are associated with the activation of the inhibitor
κB kinase (IKK) complex. However, the precise molecular mechanisms by which IKK may …
One mechanism mediating insulin resistance may involve the phosphorylation of serine
residues in insulin receptor substrate-1 (IRS-1), leading to impairment in the ability of IRS-1
to activate downstream phosphatidylinositol 3-kinase-dependent pathways. Insulin-resistant
states and serine phosphorylation of IRS-1 are associated with the activation of the inhibitor
κB kinase (IKK) complex. However, the precise molecular mechanisms by which IKK may …