Effect of prenatal supplementation with vitamin D on asthma or recurrent wheezing in offspring by age 3 years: the VDAART randomized clinical trial

AA Litonjua, VJ Carey, N Laranjo, BJ Harshfield… - Jama, 2016 - jamanetwork.com
Importance Asthma and wheezing begin early in life, and prenatal vitamin D deficiency has
been variably associated with these disorders in offspring. Objective To determine whether
prenatal vitamin D (cholecalciferol) supplementation can prevent asthma or recurrent
wheeze in early childhood. Design, Setting, and Participants The Vitamin D Antenatal
Asthma Reduction Trial was a randomized, double-blind, placebo-controlled trial conducted
in 3 centers across the United States. Enrollment began in October 2009 and completed …