Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre‐eclampsia
AW Shand, N Nassar, P Von Dadelszen… - … Journal of Obstetrics …, 2010 - Wiley Online Library
BJOG: An International Journal of Obstetrics & Gynaecology, 2010•Wiley Online Library
Please cite this paper as: Shand A, Nassar N, Von Dadelszen P, Innis S, Green T. Maternal
vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for
pre‐eclampsia. BJOG 2010; 117: 1593–1598. Objective To determine in a group of pregnant
women if vitamin D status, based on serum 25‐hydroxyvitamin D (25OHD) concentration,
was associated with a subsequent risk of pre‐eclampsia or adverse pregnancy outcomes.
Design Prospective cohort study. Setting Vancouver, British Columbia, Canada (49° N) …
vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for
pre‐eclampsia. BJOG 2010; 117: 1593–1598. Objective To determine in a group of pregnant
women if vitamin D status, based on serum 25‐hydroxyvitamin D (25OHD) concentration,
was associated with a subsequent risk of pre‐eclampsia or adverse pregnancy outcomes.
Design Prospective cohort study. Setting Vancouver, British Columbia, Canada (49° N) …
Please cite this paper as: Shand A, Nassar N, Von Dadelszen P, Innis S, Green T. Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre‐eclampsia. BJOG 2010;117:1593–1598.
Objective To determine in a group of pregnant women if vitamin D status, based on serum 25‐hydroxyvitamin D (25OHD) concentration, was associated with a subsequent risk of pre‐eclampsia or adverse pregnancy outcomes.
Design Prospective cohort study.
Setting Vancouver, British Columbia, Canada (49°N).
Population Women attending a specialist antenatal clinic because of clinical or biochemical risk factors for pre‐eclampsia (n = 221).
Methods Serum 25OHD concentration measured between 10 and 20 weeks of gestation.
Main outcome measures Pre‐eclampsia and composite adverse pregnancy outcomes.
Results Of the women, 78% were vitamin D insufficient (25OHD <75 nmol/l) and 53% were vitamin D deficient (25OHD <50 nmol/l). There was no difference in the rates of pre‐eclampsia, gestational hypertension, preterm birth or composite adverse pregnancy outcomes by 25OHD concentration.
Conclusions Vitamin D deficiency and insufficiency were common in a group of women at high risk of pre‐eclampsia; however, it was not associated with subsequent risk of an adverse pregnancy outcome.
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