A mouse model of angiotensin II slow pressor response: role of oxidative stress
N Kawada, E Imai, A Karber, WJ Welch… - Journal of the …, 2002 - journals.lww.com
The slow pressor response to prolonged infusions of angiotensin II (AngII) entails a delayed
rise in BP. This study investigated the hypothesis that the response depends on the
generation of oxidative stress. The BP and renal functional response of mice to graded
doses (200, 400, and 1000 ng· kg− 1· min− 1) of subcutaneously infused AngII was studied.
The SBP of conscious mice increased by day 3 at AngII1000 but showed a delayed rise by
days 9 to 13 (slow pressor response) at the lower rates of AngII infusion. By day 13, there …
rise in BP. This study investigated the hypothesis that the response depends on the
generation of oxidative stress. The BP and renal functional response of mice to graded
doses (200, 400, and 1000 ng· kg− 1· min− 1) of subcutaneously infused AngII was studied.
The SBP of conscious mice increased by day 3 at AngII1000 but showed a delayed rise by
days 9 to 13 (slow pressor response) at the lower rates of AngII infusion. By day 13, there …