Circadian rhythms and levels of β-endorphin, ACTH, and cortisol during chronic methadone maintenance treatment in humans
MJ Kreek, SL Wardlaw, N Hartman, J Raghunath… - Life sciences, 1983 - Elsevier
MJ Kreek, SL Wardlaw, N Hartman, J Raghunath, J Friedman, B Schneider, AG Frantz
Life sciences, 1983•ElsevierPrevious studies have shown alterations of neuroendocrine function in humans receiving
any narcotic on short-term basis or short-acting narcotics on a chronic basis. In this study of
16 well-stabilized patients, it was demonstrated that normalization of hypothalamic-pituitary
adrenal axis function, as reflected by normal levels and normal circadian rhthm of levels of β-
endorphin, ACTH and cortisol, is achieved during long-term steady state methadone
maintenance treatment of former heroin addicts.
any narcotic on short-term basis or short-acting narcotics on a chronic basis. In this study of
16 well-stabilized patients, it was demonstrated that normalization of hypothalamic-pituitary
adrenal axis function, as reflected by normal levels and normal circadian rhthm of levels of β-
endorphin, ACTH and cortisol, is achieved during long-term steady state methadone
maintenance treatment of former heroin addicts.
Abstract
Previous studies have shown alterations of neuroendocrine function in humans receiving any narcotic on short-term basis or short-acting narcotics on a chronic basis. In this study of 16 well-stabilized patients, it was demonstrated that normalization of hypothalamic-pituitary adrenal axis function, as reflected by normal levels and normal circadian rhthm of levels of β-endorphin, ACTH and cortisol, is achieved during long-term steady state methadone maintenance treatment of former heroin addicts.
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