[HTML][HTML] Dissection of the NF-κB signalling cascade in transgenic and knockout mice

M Pasparakis, T Luedde… - Cell Death & …, 2006 - nature.com
M Pasparakis, T Luedde, M Schmidt-Supprian
Cell Death & Differentiation, 2006nature.com
Studies in transgenic and knockout mice have made a major contribution to our current
understanding of the physiological functions of the NF-κB signalling cascade. The
generation and analysis of mice with targeted modifications of individual components of the
NF-κB pathway tremendously advanced our knowledge of the roles of the NF-κB proteins
themselves, and also of the many activators and negative regulators of NF-κB. These studies
have highlighted the complexity of the NF-κB system, by revealing the multiple interactions …
Abstract
Studies in transgenic and knockout mice have made a major contribution to our current understanding of the physiological functions of the NF-κB signalling cascade. The generation and analysis of mice with targeted modifications of individual components of the NF-κB pathway tremendously advanced our knowledge of the roles of the NF-κB proteins themselves, and also of the many activators and negative regulators of NF-κB. These studies have highlighted the complexity of the NF-κB system, by revealing the multiple interactions, redundancies, but also diverse functions, performed by the different molecules participating in the regulation of NF-κB signalling. Furthermore, inhibition or enforced activation of NF-κB in transgenic mice has uncovered the critical roles that NF-κB plays in the pathogenesis of various diseases such as liver failure, diabetes and cancer.
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