Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis
JK Gittler, A Shemer, M Suárez-Fariñas… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Atopic dermatitis (AD) is a common disease with an increasing prevalence.
The primary pathogenesis of the disease is still elusive, resulting in the lack of specific
treatments. AD is currently considered a biphasic disease, with TH2 predominating in acute
disease and a switch to TH1 characterizing chronic disease. Elucidation of the molecular
factors that participate in the onset of new lesions and maintenance of chronic disease is
critical for the development of targeted therapeutics. OBJECTIVES: We sought to …
The primary pathogenesis of the disease is still elusive, resulting in the lack of specific
treatments. AD is currently considered a biphasic disease, with TH2 predominating in acute
disease and a switch to TH1 characterizing chronic disease. Elucidation of the molecular
factors that participate in the onset of new lesions and maintenance of chronic disease is
critical for the development of targeted therapeutics. OBJECTIVES: We sought to …