Interleukin-1 (IL-1) is a potent inflammatory cytokine that plays a central role in the innate immune response. IL-1 mediates the acute phase of inflammation by inducing local and systemic responses, such as pain sensitivity, fever, vasodilation, and hypotension. It also promotes the expression of adhesion molecules on endothelial cells, which allows the infiltration of inflammatory and immunocompetent cells into the tissues. The release of IL-1 from the epidermis after activation is a primary event that promotes inflammatory skin conditions through the induction of various cytokines, proinflammatory mediators, and adhesion molecules.