The cutaneous innate immune response in patients with atopic dermatitis

IH Kuo, T Yoshida, A De Benedetto, LA Beck - Journal of allergy and clinical …, 2013 - Elsevier
Orchestrating when and how the cutaneous innate immune system should respond to
commensal or pathogenic microbes is a critical function of the epithelium. The cutaneous
innate immune system is a key determinant of the physical, chemical, microbial, and
immunologic barrier functions of the epidermis. A malfunction in this system can lead to an
inadequate host response to a pathogen or a persistent inflammatory state. Atopic dermatitis
is the most common inflammatory skin disorder and characterized by abnormalities in both …