Purinergic signaling and blood vessels in health and disease
G Burnstock, V Ralevic - Pharmacological reviews, 2014 - Elsevier
Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from
perivascular sympathetic nerves to cause vasoconstriction via P2X 1 receptors, whereas
ATP released from endothelial cells in response to changes in blood flow (producing shear
stress) or hypoxia acts on P2X and P2Y receptors on endothelial cells to produce nitric oxide
and endothelium-derived hyperpolarizing factor, which dilates vessels. ATP is also released …
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from
perivascular sympathetic nerves to cause vasoconstriction via P2X 1 receptors, whereas
ATP released from endothelial cells in response to changes in blood flow (producing shear
stress) or hypoxia acts on P2X and P2Y receptors on endothelial cells to produce nitric oxide
and endothelium-derived hyperpolarizing factor, which dilates vessels. ATP is also released …
