[HTML][HTML] PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ

CY Liu, X Lv, T Li, Y Xu, X Zhou, S Zhao, Y Xiong… - Journal of Biological …, 2011 - ASBMB
The Hippo pathway regulates organ size by controlling both cell proliferation and apoptosis.
TAZ functions as a transcriptional co-activator downstream of the Hippo pathway and has
been implicated in human cancer development. A key step in the Hippo-TAZ pathway is
phosphorylation of TAZ by LATS kinase, which leads to TAZ inhibition by both cytoplasmic
retention and degradation. However, the mechanism of TAZ dephosphorylation and the
responsible phosphatase are unknown. Here, we identified PP1 as a bona fide TAZ …