Interleukin-33 (IL-33) is a novel member of the IL-1 cytokine family. It has been shown to
elicit a Th2-like cytokine response in immunocompetent cells through binding and activation
of the T1/ST2 receptor. IL-33 has recently been associated with immune responses to
helminthic intestinal infections, airway inflammation and arthritis in animal models. We now
report IL-33 to be produced by colonic epithelial cells in humans and it is highly upregulated
in ulcerative colitis (UC). Little mRNA expression was found in control subjects (N= 9) …