[HTML][HTML] Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

D Banerjee, SM Mandal, A Das, ML Hegde… - Journal of Biological …, 2011 - ASBMB
Preferential repair of bulky DNA adducts from the transcribed genes via nucleotide excision
repair is well characterized in mammalian cells. However, definitive evidence is lacking for
similar repair of oxidized bases, the major endogenous DNA lesions. Here we show that the
oxidized base-specific human DNA glycosylase NEIL2 associates with RNA polymerase II
and the transcriptional regulator heterogeneous nuclear ribonucleoprotein-U (hnRNP-U),
both in vitro and in cells. NEIL2 immunocomplexes from cell extracts preferentially repaired …