Interferon (IFN)-γ is a cytokine known for its immunomodulatory and anti-proliferative action.
In the liver, IFN-γ can induce hepatocyte apoptosis or inhibit hepatocyte cell cycle
progression. This article reviews recent mechanistic reports that describe how IFN-γ may
direct the fate of hepatocytes either towards apoptosis or a cell cycle arrest. This review also
describes a probable role for IFN-γ in modulating hepatocyte fate during liver regeneration,
transplantation, hepatitis, fibrosis and hepatocellular carcinoma, and highlights promising …