Glioblastoma (GBM) is extremely aggressive and essentially incurable. Its malignancy is
characterized by vigorous microvascular proliferations. Recent evidence has shown that
tumor cells display the ability to drive blood-perfused vasculogenic mimicry (VM), an
alternative microvascular circulation independent of endothelial cell angiogenesis.
However, molecular mechanisms underlying this vascular pathogenesis are poorly
understood. Here, we found that vascular channels of VM in GBM were composed of mural …