[PDF][PDF] Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity

Y Huang, M Snuderl, RK Jain - Cancer cell, 2011 - cell.com
Y Huang, M Snuderl, RK Jain
Cancer cell, 2011cell.com
Vascular normalization is an emerging concept in cancer treatment. In this issue of Cancer
Cell, Rolny et al. show that histidine-rich glycoprotein normalizes tumor vessels and
promotes antitumor immunity by polarizing tumor-associated macrophages, leading to
decreased tumor growth and metastasis. Placental Growth Factor deletion in macrophages
phenocopies many of these effects.
Vascular normalization is an emerging concept in cancer treatment. In this issue of Cancer Cell, Rolny et al. show that histidine-rich glycoprotein normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis. Placental Growth Factor deletion in macrophages phenocopies many of these effects.
cell.com