[45] Measurement of O2− production by human neutrophils. The preparation and assay of NADPH oxidase-containing particles from human neutrophils
M Markert, PC Andrews, BM Babior - Methods in enzymology, 1984 - Elsevier
Publisher Summary Neutrophils are phagocytic cells whose principal function is the
destruction of invading bacteria. Bacterial killing is largely accomplished by means of an
oxygen-dependent microbicidal system that employs, as antimicrobial agents, a group of
lethal oxidants that the neutrophils generate when stimulated by bacterial targets. The
precursor of these lethal oxidants is O 2-. This substance is manufactured from oxygen by
stimulated neutrophils and is subsequently converted into highly reactive lethal oxidants …
destruction of invading bacteria. Bacterial killing is largely accomplished by means of an
oxygen-dependent microbicidal system that employs, as antimicrobial agents, a group of
lethal oxidants that the neutrophils generate when stimulated by bacterial targets. The
precursor of these lethal oxidants is O 2-. This substance is manufactured from oxygen by
stimulated neutrophils and is subsequently converted into highly reactive lethal oxidants …