[HTML][HTML] Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils
JL Johnson, H Hong, J Monfregola, WB Kiosses… - Journal of biological …, 2011 - ASBMB
LPS is an efficient sensitizer of the neutrophil exocytic response to a second stimulus.
Although neutrophil exocytosis in response to pathogen-derived molecules plays an
important role in the innate immune response to infections, the molecular mechanism
underlying LPS-dependent regulation of neutrophil exocytosis is currently unknown. The
small GTPase Rab27a and its effector Munc13-4 regulate exocytosis in hematopoietic cells.
Whether Rab27a and Munc13-4 modulate discrete steps or the same steps during …
Although neutrophil exocytosis in response to pathogen-derived molecules plays an
important role in the innate immune response to infections, the molecular mechanism
underlying LPS-dependent regulation of neutrophil exocytosis is currently unknown. The
small GTPase Rab27a and its effector Munc13-4 regulate exocytosis in hematopoietic cells.
Whether Rab27a and Munc13-4 modulate discrete steps or the same steps during …