[HTML][HTML] Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner
Sphingosine kinase 1 (SK1) is an important enzyme involved in the production of the
bioactive lipid sphingosine 1-phosphate (S1P). SK1 is overexpressed in many forms of
cancer, however, the contribution of SK1 to cancer progression is still unclear. One of the
best characterized mutations found in several forms of human cancer is an activating point
mutation in the Ras oncogene, which disrupts its GTPase activity and leads to stimulation of
the MEK/ERK pathway. Because SK1 activity and subcellular localization have been shown …
bioactive lipid sphingosine 1-phosphate (S1P). SK1 is overexpressed in many forms of
cancer, however, the contribution of SK1 to cancer progression is still unclear. One of the
best characterized mutations found in several forms of human cancer is an activating point
mutation in the Ras oncogene, which disrupts its GTPase activity and leads to stimulation of
the MEK/ERK pathway. Because SK1 activity and subcellular localization have been shown …