Arginine deprivation in cancer therapy

LG Feun, MT Kuo, N Savaraj - Current Opinion in Clinical Nutrition …, 2015 - journals.lww.com
LG Feun, MT Kuo, N Savaraj
Current Opinion in Clinical Nutrition & Metabolic Care, 2015journals.lww.com
Recently, there has been increased interest in tumor metabolism as an approach to treat
certain malignancies. Amino acid depletion with L-asparaginase has been used to treat
acute lymphoblastic leukemia [1]. Arginine (Arg) is also another nonessential amino acid in
adult humans. It is synthesized from citrulline by way of two key enzymes, argininosuccinate
synthetase (ASS) and argininosuccinate lyase (ASL)(see Fig. 1)[2]. Tumors that lack ASS
are unable to synthesize Arg and are therefore susceptible to Arg deprivation therapy using …
Recently, there has been increased interest in tumor metabolism as an approach to treat certain malignancies. Amino acid depletion with L-asparaginase has been used to treat acute lymphoblastic leukemia [1]. Arginine (Arg) is also another nonessential amino acid in adult humans. It is synthesized from citrulline by way of two key enzymes, argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL)(see Fig. 1)[2]. Tumors that lack ASS are unable to synthesize Arg and are therefore susceptible to Arg deprivation therapy using Arg deiminase which is derived from mycoplasma or human recombinant arginase. This review will focus on Arg and specifically on Arg deprivation for cancer therapy [3].
Lippincott Williams & Wilkins