Soluble factors from Plasmodium falciparum-infected erythrocytes induce apoptosis in human brain vascular endothelial and neuroglia cells
NO Wilson, MB Huang, W Anderson, V Bond… - Molecular and …, 2008 - Elsevier
The severity of malaria is multi-factorial. It is associated with parasite-induced alteration in
pro-inflammatory and anti-inflammatory cytokine and chemokine levels in host serum and
cerebrospinal fluid. It is also associated with sequestration and cytoadherence of parasitized
erythrocytes (pRBCs) in post-capillary venules and blood–brain barrier (BBB) dysfunction.
The role of these factors in development of vascular injury and tissue damage in malaria
patients is unclear. While some studies indicate a requirement for pRBC adhesion to …
pro-inflammatory and anti-inflammatory cytokine and chemokine levels in host serum and
cerebrospinal fluid. It is also associated with sequestration and cytoadherence of parasitized
erythrocytes (pRBCs) in post-capillary venules and blood–brain barrier (BBB) dysfunction.
The role of these factors in development of vascular injury and tissue damage in malaria
patients is unclear. While some studies indicate a requirement for pRBC adhesion to …