Modulation of tight junction structure and function by cytokines
SV Walsh, AM Hopkins, A Nusrat - Advanced drug delivery reviews, 2000 - Elsevier
SV Walsh, AM Hopkins, A Nusrat
Advanced drug delivery reviews, 2000•ElsevierDynamic regulation of tight junction function is fundamental to many physiologic processes.
Disruption of tight junction function drastically alters paracellular permeability and is a
hallmark of many pathologic states. Recently, an increasing number of cytokines have been
shown to influence tight junction function both in vitro and in vivo. Cytokine-induced effects
on tight junction barrier function have also been correlated with effects on intrinsic tight
junction proteins and the associated actin cytoskeleton. The aim of this article is to review …
Disruption of tight junction function drastically alters paracellular permeability and is a
hallmark of many pathologic states. Recently, an increasing number of cytokines have been
shown to influence tight junction function both in vitro and in vivo. Cytokine-induced effects
on tight junction barrier function have also been correlated with effects on intrinsic tight
junction proteins and the associated actin cytoskeleton. The aim of this article is to review …
Dynamic regulation of tight junction function is fundamental to many physiologic processes. Disruption of tight junction function drastically alters paracellular permeability and is a hallmark of many pathologic states. Recently, an increasing number of cytokines have been shown to influence tight junction function both in vitro and in vivo. Cytokine-induced effects on tight junction barrier function have also been correlated with effects on intrinsic tight junction proteins and the associated actin cytoskeleton. The aim of this article is to review studies relating to the effects of cytokines on tight junction function and structure.
Elsevier