[HTML][HTML] PHD3 stabilizes the tight junction protein occludin and protects intestinal epithelial barrier function
Y Chen, HS Zhang, GH Fong, QL Xi, GH Wu… - Journal of Biological …, 2015 - ASBMB
Prolyl hydroxylase domain proteins (PHDs) control cellular adaptation to hypoxia. PHDs are
found involved in inflammatory bowel disease (IBD); however, the exact role of PHD3, a
member of the PHD family, in IBD remains unknown. We show here that PHD3 plays a
critical role in maintaining intestinal epithelial barrier function. We found that genetic ablation
of Phd3 in intestinal epithelial cells led to spontaneous colitis in mice. Deletion of PHD3
decreases the level of tight junction protein occludin, leading to a failure of intestinal …
found involved in inflammatory bowel disease (IBD); however, the exact role of PHD3, a
member of the PHD family, in IBD remains unknown. We show here that PHD3 plays a
critical role in maintaining intestinal epithelial barrier function. We found that genetic ablation
of Phd3 in intestinal epithelial cells led to spontaneous colitis in mice. Deletion of PHD3
decreases the level of tight junction protein occludin, leading to a failure of intestinal …