Changes in the rat intestine after x-irradiation of exteriorized short segments of ileum

JW Osborne, KN Prasad… - Radiation …, 1970 - meridian.allenpress.com
JW Osborne, KN Prasad, GR Zimmerman
Radiation Research, 1970meridian.allenpress.com
Segments of rat ileum 2.5 or 7.5 cm in length were x-irradiated with 3000 R or 5000 R under
conditions of normal or restricted blood flow to the intestine. Most animals were allowed to
live their life span for mortality studies, but others were killed between Day 5 and Day 44 for
an assessment of the progression of histological changes in the irradiated segment. Time of
death after irradiation was variable in each treatment category. Most animals died between
10 and 100 days; some lived beyond 200 days. The blood flow-restriction procedure …
Segments of rat ileum 2.5 or 7.5 cm in length were x-irradiated with 3000 R or 5000 R under conditions of normal or restricted blood flow to the intestine. Most animals were allowed to live their life span for mortality studies, but others were killed between Day 5 and Day 44 for an assessment of the progression of histological changes in the irradiated segment. Time of death after irradiation was variable in each treatment category. Most animals died between 10 and 100 days; some lived beyond 200 days. The blood flow-restriction procedure extended the life span in the 3000 R-7.5-cm group, but was ineffective at 5000 R regardless of segment length. A lesion characterized by serosal fibrosis apparently secondary to mucosal ulceration was always produced, but the latent period between the events and the extent of fibrosis varied considerably. Death was almost always due to bowel obstruction. In the 2.5-cm segment exposed to 5000 R, the mucosa did not regenerate in 44 days, but in some of the 7.5-cm segments subjected to 3000 R, it did. The regeneration of mucosa was not an effective deterrent to the development of fibrosis as none of the animals lived a normal life span and when autopsied, an intestinal lesion was found.
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