B-cell depletion using an anti-CD20 antibody augments antitumor immune responses and immunotherapy in nonhematopoetic murine tumor models
S Kim, ZG Fridlender, R Dunn, MR Kehry… - Journal of …, 2008 - journals.lww.com
The role played by B cells in cancer biology is complex and somewhat controversial.
Previous studies using genetically engineered mice suggest that B cells may be
immunosuppressive and inhibit tumor rejection. However, the effects of B-cell depletion
employing an antibody in mice bearing solid tumors has not been tested owing to difficulties
in making an effective antimouse CD20 antibody (similar to rituximab). Injection of a newly
developed antimouse CD20 antibody was effective in depleting circulating B cells from …
Previous studies using genetically engineered mice suggest that B cells may be
immunosuppressive and inhibit tumor rejection. However, the effects of B-cell depletion
employing an antibody in mice bearing solid tumors has not been tested owing to difficulties
in making an effective antimouse CD20 antibody (similar to rituximab). Injection of a newly
developed antimouse CD20 antibody was effective in depleting circulating B cells from …