[HTML][HTML] Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin
SU Jaeger, BO Schroeder, U Meyer-Hoffert, L Courth… - Mucosal …, 2013 - Elsevier
Abstract Human β-defensin 1 (hBD-1) is an antimicrobial peptide expressed by epithelia and
hematopoietic cells. We demonstrated recently that hBD-1 shows activity against enteric
commensals and Candida species only after its disulfide bonds have been reduced by
thioredoxin (TRX) or a reducing environment. Here we show that besides TRX, glutaredoxin
(GRX) is also able to reduce hBD-1, although with far less efficacy. Moreover, living
intestinal and lymphoid cells can effectively catalyze reduction of extracellular hBD-1. By …
hematopoietic cells. We demonstrated recently that hBD-1 shows activity against enteric
commensals and Candida species only after its disulfide bonds have been reduced by
thioredoxin (TRX) or a reducing environment. Here we show that besides TRX, glutaredoxin
(GRX) is also able to reduce hBD-1, although with far less efficacy. Moreover, living
intestinal and lymphoid cells can effectively catalyze reduction of extracellular hBD-1. By …