[HTML][HTML] Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and …
A Chittka, J Nitarska, U Grazini… - Journal of Biological …, 2012 - ASBMB
During development of the cerebral cortex, neural stem cells (NSCs) undergo a temporal
switch from proliferative (symmetric) to neuron-generating (asymmetric) divisions. We
investigated the role of Schwann cell factor 1 (SC1/PRDM4), a member of the PRDM family
of transcription factors, in this critical transition. We discovered that SC1 recruits the
chromatin modifier PRMT5, an arginine methyltransferase that catalyzes symmetric
dimethylation of histone H4 arginine 3 (H4R3me2s) and that this modification is …
switch from proliferative (symmetric) to neuron-generating (asymmetric) divisions. We
investigated the role of Schwann cell factor 1 (SC1/PRDM4), a member of the PRDM family
of transcription factors, in this critical transition. We discovered that SC1 recruits the
chromatin modifier PRMT5, an arginine methyltransferase that catalyzes symmetric
dimethylation of histone H4 arginine 3 (H4R3me2s) and that this modification is …