Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis
V Ödemis, E Lamp, G Pezeshki, B Moepps… - Molecular and Cellular …, 2005 - Elsevier
The chemokine CXCL12/SDF-1 and its receptor CXCR4 regulate the development and the
function of the hematopoietic system and control morphogenesis of distinct brain areas.
Here, we demonstrate that inactivation of CXCR4 results in a massive loss of spinal cord
motoneurons and dorsal root ganglion neurons and, subsequently, in a reduced innervation
of the developing mouse fore-and hindlimbs. However, only the death of sensory neurons
seems to be a direct consequence of receptor inactivation as suggested by the observations …
function of the hematopoietic system and control morphogenesis of distinct brain areas.
Here, we demonstrate that inactivation of CXCR4 results in a massive loss of spinal cord
motoneurons and dorsal root ganglion neurons and, subsequently, in a reduced innervation
of the developing mouse fore-and hindlimbs. However, only the death of sensory neurons
seems to be a direct consequence of receptor inactivation as suggested by the observations …