[HTML][HTML] Cells of the synovium in rheumatoid arthritis. Macrophages

RW Kinne, B Stuhlmüller, GR Burmester - Arthritis research & therapy, 2007 - Springer
RW Kinne, B Stuhlmüller, GR Burmester
Arthritis research & therapy, 2007Springer
The multitude and abundance of macrophage-derived mediators in rheumatoid arthritis and
their paracrine/autocrine effects identify macrophages as local and systemic amplifiers of
disease. Although uncovering the etiology of rheumatoid arthritis remains the ultimate
means to silence the pathogenetic process, efforts in understanding how activated
macrophages influence disease have led to optimization strategies to selectively target
macrophages by agents tailored to specific features of macrophage activation. This …
Abstract
The multitude and abundance of macrophage-derived mediators in rheumatoid arthritis and their paracrine/autocrine effects identify macrophages as local and systemic amplifiers of disease. Although uncovering the etiology of rheumatoid arthritis remains the ultimate means to silence the pathogenetic process, efforts in understanding how activated macrophages influence disease have led to optimization strategies to selectively target macrophages by agents tailored to specific features of macrophage activation. This approach has two advantages: (a) striking the cell population that mediates/amplifies most of the irreversible tissue destruction and (b) sparing other cells that have no (or only marginal) effects on joint damage.
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