[HTML][HTML] A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
Hypoxia triggers a reversible inhibition of protein synthesis thought to be important for
energy conservation in O 2-deficient environments. The mammalian target of rapamycin
(mTOR) pathway integrates multiple environmental cues to regulate translation in response
to nutrient availability and stress, suggesting it as a candidate for O 2 regulation. We show
here that hypoxia rapidly and reversibly triggers hypophosphorylation of mTOR and its
effectors 4E-BP1, p70 S6K, rpS6, and eukaryotic initiation factor 4G. Hypoxic regulation of …
energy conservation in O 2-deficient environments. The mammalian target of rapamycin
(mTOR) pathway integrates multiple environmental cues to regulate translation in response
to nutrient availability and stress, suggesting it as a candidate for O 2 regulation. We show
here that hypoxia rapidly and reversibly triggers hypophosphorylation of mTOR and its
effectors 4E-BP1, p70 S6K, rpS6, and eukaryotic initiation factor 4G. Hypoxic regulation of …