Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species

EL Bell, NS Chandel - Essays in biochemistry, 2007 - portlandpress.com
Essays in biochemistry, 2007portlandpress.com
Decreased oxygen availability (hypoxia) promotes physiological processes such as energy
metabolism, angiogenesis, cell proliferation and cell viability through the transcription factor
HIF (hypoxia-inducible factor). Activation of HIF can also promote pathophysiological
processes such as cancer and pulmonary hypertension. The mechanism (s) by which
hypoxia activates HIF are the subject of intensive research. In this chapter we outline the
model in which mitochondria regulate the stability of HIF through the increased production of …
Decreased oxygen availability (hypoxia) promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation and cell viability through the transcription factor HIF (hypoxia-inducible factor). Activation of HIF can also promote pathophysiological processes such as cancer and pulmonary hypertension. The mechanism(s) by which hypoxia activates HIF are the subject of intensive research. In this chapter we outline the model in which mitochondria regulate the stability of HIF through the increased production of ROS (reactive oxygen species) during hypoxia.
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