[HTML][HTML] Hypoxic regulation of lactate dehydrogenase A: interaction between hypoxia-inducible factor 1 and cAMP response elements (∗)
JD Firth, BL Ebert, PJ Ratcliffe - Journal of Biological Chemistry, 1995 - ASBMB
The oxygen-regulated control system responsible for the induction of erythropoietin (Epo) by
hypoxia is present in most (if not all) cells and operates on other genes, including those
involved in energy metabolism. To understand the organization of cis-acting sequences that
are responsible for oxygen-regulated gene expression, we have studied the 5′ flanking
region of the mouse gene encoding the hypoxically inducible enzyme lactate
dehydrogenase A (LDH). Deletional and mutational analysis of the function of mouse LDH …
hypoxia is present in most (if not all) cells and operates on other genes, including those
involved in energy metabolism. To understand the organization of cis-acting sequences that
are responsible for oxygen-regulated gene expression, we have studied the 5′ flanking
region of the mouse gene encoding the hypoxically inducible enzyme lactate
dehydrogenase A (LDH). Deletional and mutational analysis of the function of mouse LDH …