[HTML][HTML] 6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia
M Obach, À Navarro-Sabaté, J Caro, X Kong… - Journal of Biological …, 2004 - ASBMB
The up-regulation of glycolysis to enhance the production of energy under reduced pO 2 is a
hallmark of the hypoxic response. A key regulator of glycolytic flux is fructose-2, 6-
bisphosphate, and its steady state concentration is regulated by the action of different
isozymes product of four genes (pfkfb1–4). pfkfb3 has been found in proliferating cells and
tumors, being induced by hypoxia. To understand the organization of cis-acting sequences
that are responsible for the oxygen-regulated pfkfb3 gene, we have studied its 5′-flanking …
hallmark of the hypoxic response. A key regulator of glycolytic flux is fructose-2, 6-
bisphosphate, and its steady state concentration is regulated by the action of different
isozymes product of four genes (pfkfb1–4). pfkfb3 has been found in proliferating cells and
tumors, being induced by hypoxia. To understand the organization of cis-acting sequences
that are responsible for the oxygen-regulated pfkfb3 gene, we have studied its 5′-flanking …